Professional Reviews- “Although most of future E63 owners won't find themselves lapping a racetrack in anger, these cars can handle it.” — Road & Track
- “I do love the steering, however, and the perfectly shaped, Alcantara-covered steering wheel is bliss. Mercedes' Comand system has evolved into one of the best multimedia interfaces, and the dash layout and logic are pretty commendable all around.” — Automobile
- “There's no lag, lumps or bumps in its lionhearted power curve, and it pulls hard, fast and long, never out of breath. Mercedes claims a 0-60 time in the low 4-second range, which we don't question.” — Edmunds.com
- “I suppose, however, I can muster some criticisms. The E63's ride is pretty brittle, and that's before you crank up the damper firmness to hard or harder. The auto stop-start mode, which I found so unobtrusive in the CL63 AMG, is somehow much more annoying here.” — Automobile
- “Mercedes hasn't exactly blazed its own design trail by squaring off the headlamps in a manner reminiscent of the Lexus GS and fitting Audi-like LED light bars in the lower fascia. Also, the rear of the Mercedes is almost indistinguishable from other sedans in its segment.” — Road & Track
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